Nembutal sodium solution Injection 250mg/ml ( Lethal dose 20ml) is a short-acting barbiturate, chemically designated as sodium 5-ethyl-5-(1-methylbutyl) barbiturate. This is one of the reasons for being more suitable for suicide than longer-acting barbiturates such as phenobarbital.
Nembutal sodium solution Injection 250mg/ml ( Lethal dose 20ml) is a proven, reliable drug that brings about a peaceful death. Almost no failures are known, despite large statistics (for example, the Swiss euthanasia organisation Dignitas reported 840 exits with no single failure). There are however reports on seemingly slow or painful deaths with Nembutal in capital punishment, although this may be due to poor quality of the drug from compounding pharmacies given intravenously rather than orally.
DOSAGE AND ADMINISTRATION
Nembutal sodium solution Injection 250mg/ml ( Lethal dose 20ml) is sold most of the time in liquid form for use as a sedative and anesthetic in hospitals. veterinary Nembutal is a liquid and not in pill-form, which means that it has a shorter shelf life. On the other hand, Seconal (secobarbital), a short acting barbiturate that is as powerful as Nembutal if not more powerful, is still available in capsule form in the USA, EUROPE and probably the UK. Nembutal pills has a bitter taste that require the use of anti-emetics to prevent vomiting when given orally at high dosages.
It is easy from today form today to obtain vials of Nembutal Pentobarbital 250mg/ml (pentobarbital sodium injection), a sterile solution for intravenous or intramuscular injection, typically used for animal anaesthesia or euthanasia. Each mL contains pentobarbital sodium 50 mg ,100 mg or 250mg (lethal dose) in a vehicle of approximately propylene glycol, 40%, alcohol, 10% and water for injection, to volume. The pH is adjusted to approximately 9.5 with hydrochloric acid and/or sodium hydroxide. The range of actual pentobarbital sodium in a vial may vary between 3 g to 15. The containers come in a clear vial typical for sterile solutions, and should have an untouched protective metal cap if unopened, and be labelled clearly with due date. The nembutal solution may be taken intravenously, for very quick effect as in capital punishment, or orally.
Dosages of barbiturates must be individualized with full knowledge of their particular characteristics and recommended rate of administration. Factors of consideration are the patient’s age, weight, and condition. Parenteral routes should be used only when oral administration is impossible or impractical.
Intramuscular Administration: IM injection of the sodium salts of barbiturates should be made deeply into a large muscle,
Intravenous Administration: NEMBUTAL (pentobarbital) Sodium SolutioNembutal Pentobarbital 250mg/ml should not be admixed with any other medication or solution. IV injection is restricted to conditions in which other routes are not feasible, either because the patient is unconscious (as in cerebral hemorrhage, eclampsia, or status epilepticus), or because the patient resists (as in delirium), or because prompt action is imperative. Slow IV injection is essential, and patients should be carefully observed during administration. This requires that blood pressure, respiration, and cardiac function be maintained, vital signs be recorded, and equipment for resuscitation and artificial ventilation be available.
dosage of Nembutal sodium solution (pentobarbital) lethal dose is 250mg/ml (20ml). The injection must be made slowly with due regard to the time required for the drug to penetrate the blood-brain barrier.
Inspection: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution containers permit. Solutions for injection showing evidence of precipitation should not be used.
Potentiating the cocktail and masking the taste
It is usually recommended to drink some alcohol immediately after (not prior) to the Nembutal ingestion to potentiate its effect and mask the very bitter taste.
Eating a big meal prior to or after the drug ingestion is not recommended to reduce chances of slow drug absorption or vomiting. Dignitas offers clients chocolates to deal with the bitter taste of the drug.
Time To Death
Experience in the world has learned that after injection of 250mg/ml of lethal dose pentobarbital or secobarbital, death generally occurs within 1/2 hours maximum.
A pentobarbital overdose is an amount taken in excess of that which is medically recommended. Two to ten grams excess can cause death
In extreme overdose, all electrical activity in the brain may cease, in which case a “flat” EEG normally equated with clinical death cannot be accepted. This effect is fully reversible unless hypoxic damage occurs. Consideration should be given to the possibility of barbiturate intoxication even in situations that appear to involve trauma.
Complications such as pneumonia, pulmonary edema, cardiac arrhythmias, congestive heart failure, and renal failure may occur. Uremia may increase CNS sensitivity
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